Applies only to oral form of both agents. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Applies only to oral form of both agents. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL 1. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Copyright 2021 GlobalRPH - Web Development by. Avoid or Use Alternate Drug. Use Caution/Monitor. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Mean change in Hgb from baseline to Week 5 2,5 May increase risk of hypotension. Use Caution/Monitor. Compare formulary status to other drugs in the same class. Schweiz Med Wochenschr. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Use Caution/Monitor. Separate dosing of tetracyclines from these products. LBW = Lean body weight in kg. Corrected Sodium and Effective Osmolality. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Minor/Significance Unknown. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Do not administer Venofer to patients with iron overload. Applies only to oral form of both agents. Minor (1)iron sucrose, benazepril. Corrected Calcium. Applies only to oral form of both agents. Fulminant symptoms include confusion, sensation of passing out, paleness. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Applies only to oral form of both agents. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Applies only to oral form of both agents. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. ANNA J. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Human studies not conducted. iron sucrose decreases levels of deferiprone by enhancing GI absorption. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Minor/Significance Unknown. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. This drug is available at a higher level co-pay. Pediatric Patients (2 Years of Age and Older). Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. A: Generally acceptable. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Minor/Significance Unknown. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Ferric gluconate: 12.5 mg/mL. Kumpf VJ, Holland EG. Applies only to oral form of both agents. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Calculation of the Total Iron Deficit - Alternative equation PDF Protocol for the use of Intravenous Iron Dextran (CosmoFer Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . The dosage of Venofer is expressed in mg of elemental iron. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Dosage Calculator IV iron products (adults) - UpToDate Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Use Caution/Monitor. Applies only to oral form of both agents. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Discuss the risks and benefits with your doctor.This medication passes into breast milk. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Avoid or Use Alternate Drug. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Separate by 2 hr. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. 2010; 193(9):525-32. The dosage of Venofer is expressed in mg of elemental iron. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Accessed: 4/12/2011. Minor/Significance Unknown. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. This may be helped by giving the medication more slowly or at a lower dose. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Applies only to oral form of both agents. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. 1974 Jun;31(6):592-5. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Crown Rump Length and Nuchal Translucency. This website also contains material copyrighted by 3rd parties. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] 1000 mg. 20 MINUTES. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Avoid or Use Alternate Drug. If we don't have the calculator you need we'll try to make it for you and add it to the website. Avoid or Use Alternate Drug. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Parenteral Iron Replacement For Anemia Calculator - MDApp HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. elemental iron (mg/ml) in the product being used: Where C= All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Separate by at least 4 hours. The dosage of Venofer is expressed in mg of elemental iron. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Methods. Medicinal forms Ferritin and transferrin are also recommended monitoring . Use Caution/Monitor. commonly, these are generic drugs. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. 1970; 100(7):301-3. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. FERAHEME met the predefined criteria for non-inferiority to Venofer . Feraheme does not contain antimicrobial preservatives. 1. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. Applies only to oral form of both agents. Applies only to oral form of both agents. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Each costs about $0.46 to $0.55 per mg of iron. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Use Caution/Monitor. Avoid or Use Alternate Drug. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). and formulary information changes. If you log out, you will be required to enter your username and password the next time you visit. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. prescription products. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. 1998 Feb;25(1):65-8. We comply with the HONcode standard for trustworthy health information. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. If either is present, do not use the liquid. Avoid or Use Alternate Drug. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Max Dose. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Deferoxamine chelates iron. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption.
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